Anxiety affects millions of adults each year and is one of the most common mental health challenges in the United States. From daily stressors to more chronic worry, many people experience moments of nervousness that can interfere with sleep, focus, and overall well-being.
For those looking for immediate, non-prescription support, over-the-counter (OTC) remedies such as vitamins, herbal supplements, and mild sedating products have become a popular first choice due to their low cost and easy accessibility.
These options are generally intended for mild or situational anxiety to provide temporary relief, helping people manage stress without the need for prescription medications. They are not a replacement for treatment for anxiety disorders, but rather can be used as part of a larger, personalized wellness plan.
What Are OTC Anxiety Meds?
Over-the-counter (OTC) anxiety medications can be purchased without a prescription to help manage mild anxiety, stress, or occasional nervousness. These products are not intended to treat diagnosed anxiety disorders, but they may provide temporary relief for situational or low-level anxiety.
Millions of adults turn to OTC options as a first step before seeking prescription treatments, though data suggests that only a small portion experience significant long-term relief. Their accessibility and lower cost make them a common choice for those looking for immediate, non-prescription support [1].
OTC anxiety remedies fall into several categories, each working in different ways and with varying levels of scientific support [2]:
- Vitamins and Supplements: Often marketed for relaxation, sleep support, or stress reduction. Evidence varies, some have modest calming effects, while others are supported mostly by anecdotal reports. Common supplements used for anxiety include magnesium, B-complex vitamins, L-theanine, valerian root, chamomile, and ashwagandha.
- Non-Prescription Medications: Some antihistamines, like diphenhydramine (found in sleep aids and Benadryl), can have sedating effects that temporarily reduce anxiety symptoms. These are intended for short-term relief, especially if anxiety is induced due to an allergic reaction, and are not recommended for regular use, as they can lead to dependence.
- Homeopathic or Herbal Remedies: Herbal supplements or remedies such as kava kava and passionflower are sometimes used for mild anxiety. There is little research to support their effectiveness, and safety can vary depending on dose and preparation method.
9 Natural Over-The-Counter Supplements for Anxiety
Magnesium
Magnesium is an essential mineral for nerve and muscle function. Low magnesium levels have been linked to increased anxiety, irritability, and tension. Supplementing with magnesium may help regulate neurotransmitters and promote relaxation, potentially easing mild anxiety symptoms.
It’s often used in forms such as magnesium glycinate or citrate to improve absorption. And many report finding it beneficial in improving the quality of their sleep and relieving anxiety-induced constipation [3].
Chamomile
Chamomile is an herbal remedy commonly drunk as tea or taken in supplement form. Studies suggest chamomile can help reduce symptoms of mild generalized anxiety and improve sleep quality, and it is generally considered safe for short-term use with few side effects [4].
Valerian Root
Valerian root is an herb traditionally used to support sleep and relaxation. It can interact with neurotransmitters such as GABA to help calm the nervous system. While research on anxiety is limited, valerian is often used to manage stress-related sleep disturbances and mild nervous tension. Effects are typically mild and gradual, making it suitable for short-term use [5].
Ashwagandha
Ashwagandha is an adaptogenic herb that helps the body respond to stress. It may reduce cortisol levels and improve resistance to stress, which can indirectly reduce feelings of anxiety. Some studies show that it can decrease moderate anxiety symptoms when taken consistently. It is commonly available as capsules, powders, or extracts.
Melatonin
Melatonin is a hormone that regulates the sleep-wake cycle. While not a traditional anxiety treatment, it can help improve sleep quality, which indirectly supports emotional regulation and reduces stress. People with anxiety-related insomnia may benefit from short-term melatonin use to reset sleep patterns. It is available over-the-counter in tablet, capsule, or gummy forms.
CBD
CBD is a non-psychoactive compound derived from the cannabis plant. Research shows it interacts with receptors in the endocannabinoid system to potentially reduce anxiety and stress responses. It can be taken as oils, capsules, or edibles and is often used for situational or mild anxiety. CBD is generally well-tolerated and will not get you “high” [6].
L-Theanine
L-theanine is an amino acid found naturally in green tea. It promotes relaxation without causing drowsiness by increasing alpha brain wave activity and modulating neurotransmitters. People often use it to reduce stress and improve focus in anxious or high-pressure situations.
Omega-3 Fatty Acids
Omega-3s are essential fatty acids found in fish oil, such as salmon, flaxseed, and walnuts. They support brain health and may improve neurotransmitter function, including serotonin, which is tied to mood regulation and stress. Research shows omega-3 supplementation can modestly reduce anxiety symptoms, particularly in people with low dietary intake [7].
B Vitamins
B vitamins (like B6, B12, and folate) are water-soluble vitamins essential for nervous system function. Deficiencies can contribute to fatigue, irritability, and heightened anxiety.
Supplementing with B vitamins may help support energy metabolism and neurotransmitter production, indirectly reducing anxiety symptoms. They are available in individual forms or as part of B-complex supplements.
Signs OTC Meds Aren’t Enough and When To Seek Professional Mental Health Support
Over-the-counter (OTC) remedies for anxiety, such as supplements or herbal products, can provide temporary relief for occasional stress or mild nervousness. However, they are not a replacement for professional mental health care, and relying on them exclusively may mask symptoms rather than address underlying causes.
If anxiety persists, worsens, or interferes with daily functioning, it’s important to recognize when it’s time to seek support from a qualified mental health professional. You may need professional care if you notice any of the following signs:
- Persistent anxiety or worry that lasts most of the day and affects work, school, or relationships
- Panic attacks, intense fear, or physical symptoms like rapid heartbeat or shortness of breath
- Trouble sleeping, chronic fatigue, or difficulty concentrating despite using OTC remedies
- Dependence on OTC products or alcohol to manage anxiety symptoms
- Feelings of hopelessness, low mood, or thoughts of self-harm
Recognizing these signs early allows you to connect with therapy, prescription medications if needed, or structured behavioral programs. Mental health professionals can help identify underlying causes, provide coping strategies, and create a comprehensive plan tailored to your needs.
Evidence-Based Treatment for Anxiety in Massachusetts
Trinity Wellness Group’s full-day and half-day treatment programs in Braintree, Massachusetts, offer an ideal structure for those struggling with anxiety disorders and co-occurring substance use who need intensive or flexible support without disrupting their academic or professional lives.
We also partner closely with university students in the Boston area, many of whom are vulnerable to anxiety due to academic pressures, social transitions, and the demands of student life. By understanding the unique stressors students face, our team provides targeted, evidence-based interventions designed to help young adults manage anxiety, build resilience, and maintain their academic performance while receiving care.
To accommodate busy class schedules, extracurricular commitments, and campus life, our programs offer flexible scheduling options, including full-day and half-day programs, as well as telehealth sessions.
Contact us today to find support and begin treatment.
Sources
[1] Alzahrani, S. (2025). Attitudes and Behaviors of the Public Toward over the Counter (OTC) Medications in the Western Region of Saudi Arabia: A Cross-Sectional Study. Healthcare (Basel, Switzerland), 13(5), 472.
[2] Vieira, K. F. (2010). Nutritional and herbal supplements for anxiety and anxiety-related disorders: systematic review. Nutrition Journal, 9, 42.
[3] Tur, A. et al. (2025). Unlocking the Power of Magnesium: A Systematic Review and Meta-Analysis Regarding Its Role in Oxidative Stress and Inflammation. Antioxidants (Basel, Switzerland), 14(6), 740.
[4] Green, J. (2020). Valerian Root in Treating Sleep Problems and Associated Disorders-A Systematic Review and Meta-Analysis. Journal of evidence-based integrative medicine, 25, 2515690X20967323.
[5] Gupta, S. et al. (2010). Chamomile: A herbal medicine of the past with bright future. Molecular medicine reports, 3(6), 895–901.
[6] Noman, A. (2023). Emerging Therapeutic Potential of Cannabidiol (CBD) in Neurological Disorders: A Comprehensive Review. Behavioural neurology, 2023, 8825358.
[7] Pae, U. et al. (2015). Omega-3 Polyunsaturated Fatty Acids in Prevention of Mood and Anxiety Disorders. Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology, 13(2), 129–137.